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產品詳情
  • 產品名稱:PeptidylprolylIsomeraseA(CyclophilinA)(PPIA)Protein

  • 產品型號:
  • 產品廠商:DIATHEVA
  • 產品文檔:
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簡單介紹:
PeptidylprolylIsomeraseA(CyclophilinA)(PPIA)Protein
詳情介紹:
Purity >99?%
Background Cyclophilin A (CypA, 18 kDa) is the first peptidyl-prolil cis-trans isomerase (PPIase) to be discovered, PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. Cyclophilins belong to the superfamily of immunophilins, highly conserved cytoplasmic proteins which share the PPI enzymatic activity and the ability to bind immunosuppressive drugs. CypA binds to and mediates the effect of Cyclosporin A, the CsA/CypA complex selectively binds and inactivates the serine/theronine phosphatase calcineurin leading to disruption of T-cells activating cascade. CsA binding occurs at the active site of the protein thus inhibiting its enzymatic activity. CypA has been demonstrated to be involved in several steps of viral infections such as those mediated by HIV, HBV and HCV.
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Buffer 20?mM Tris?pH 8.0, 20?mM NaCl, 0.5?mM DTT, 10?% (v/v) glycerol
Storage -20 °C
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